Late onset epilepsy in undiagnosed tuberous sclerosis.
نویسندگان
چکیده
A 67 year old woman first developed left-sided sensorimotor seizures postoperatively in association with infection and mild hyponatraemia. She was found to have previously unrecognized tuberous sclerosis, with gross pathognomic features: periungual fibromata, facial angiofibromata, calcified subependymal nodules, cortical tubers and multiple renal angiomyolipomata. Her son who was epileptic was also found to have other mild features of tuberous sclerosis as a result. As far as we are aware our patient is the oldest for the first presentation of tuberous sclerosis.
منابع مشابه
Tuberous Sclerosis Alliance
Seizures or epilepsy are common manifestations of tuberous sclerosis. Some 80-90% of individuals with TS have seizure activity during their lifetime, often with onset in childhood. Fortunately, many children and adults with TS have seizure activity that is controlled by medication. After 1-2 years of being seizure free, it is often possible to decrease the use of medications and continue to be ...
متن کاملThe natural history of epilepsy in tuberous sclerosis complex.
BACKGROUND Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease. METHODS A retrospective chart review of all patients with TSC seen between January 2002 and October 2008. Charts were reviewed for a history of infantile spasms (IS), seizure other than IS, refractory epilepsy, Lennox-Gastaut ...
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Tuberous sclerosis is associated with epilepsy in up to 85% of cases, and in 2/3, the onset is within the first year of life. An early antiepileptic treatment is crucial to minimize the consequences of epilepsy on cognition and behavior. We present a case report of a child with tuberous sclerosis who presented with infantile spasms at the age of 6 months, immediately treated with vigabatrin. Be...
متن کاملEpilepsy in Tuberous Sclerosis: Phenotypes, Mechanisms, and Treatments.
Epilepsy affects 75% to 90% of people with tuberous sclerosis, a multisystem genetic disorder. Although seizures can occur for the first time at any age, onset in infancy or childhood is usual. Around 30% of patients present with infantile spasms that often respond well to treatment with vigabatrin. Later seizures may occur as specific patterns, such as in Lennox-Gastaut syndrome, or with combi...
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We report two cases diagnosed with Tuberous Sclerosis Complex (TSC) that showed relatively late onset developmental regression with loss of skills following onset of epileptic spasms at around two years of age. Both the cases were reported to be developing normally before the regression. The regression in both children was characterised by a sudden and dramatic loss of intellectual abilities, s...
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ورودعنوان ژورنال:
- Postgraduate medical journal
دوره 68 806 شماره
صفحات -
تاریخ انتشار 1992